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    ChemicalBook >> CAS DataBase List >>L-5-Hydroxytryptophan


    CAS No.
    Chemical Name:
    5-HTP;OXITRIPTAN;(S)-2-Amino-3-(5-hydroxy-1H-indol-3-yl)propanoic acid;L-2-AMINO-3-(5-HYDROXYINDOLYL)PROPIONIC ACID;L-5-HTP;Griffonia seed;5-hydroxy-l-tryptopha;5-Hydroxy-L-tryptophane;L-HTP;quietim
    Molecular Formula:
    Molecular Weight:
    MDL Number:
    MOL File:
    MSDS File:
    Last updated:2023-10-26 18:06:12

    L-5-Hydroxytryptophan Properties

    Melting point 270 °C (dec.) (lit.)
    alpha -32.5 º (c=1,H2O on dry basis)
    Boiling point 361.16°C (rough estimate)
    Density 0.902 g/mL at 25 °C (lit.)
    refractive index n20/D 1.4850(lit.)
    Flash point 175 °F
    storage temp. 2-8°C
    solubility H2O: 10 mg/mL
    pka 2.22±0.10(Predicted)
    form solid
    color white
    optical activity [α]22/D 30°, c = 1 in H2O
    Water Solubility Slightly soluble
    Merck 14,4847
    BRN 88200
    LogP -0.140 (est)
    CAS DataBase Reference 4350-09-8(CAS DataBase Reference)
    NCI Drug Dictionary oxitriptan
    ATC code N06AX01
    EPA Substance Registry System L-5-Hydroxytryptophan (4350-09-8)


    Risk and Safety Statements

    Symbol(GHS)  GHS hazard pictograms
    Signal word  Danger
    Hazard statements  H301
    Precautionary statements  P301+P330+P331+P310
    Hazard Codes  Xn,Xi
    Risk Statements  22-36/37/38-65-20/21/22-20/21
    Safety Statements  36-26
    RIDADR  UN 2811 6.1/PG 3
    WGK Germany  3
    RTECS  YN7110000
    TSCA  Yes
    HazardClass  6.1
    PackingGroup  III
    HS Code  29339990
    NFPA 704
    2 0

    L-5-Hydroxytryptophan price More Price(58)

    Manufacturer Product number Product description CAS number Packaging Price Updated Buy
    Sigma-Aldrich PHL80477 5-Hydroxy-L-tryptophan phyproof? Reference Substance 4350-09-8 50MG $250 2023-06-20 Buy
    Sigma-Aldrich 107751 5-Hydroxy-L-tryptophan 98% (calc. on dried substance) 4350-09-8 1g $42.7 2023-06-20 Buy
    Sigma-Aldrich PHR2597 5-Hydroxy-L-tryptophan Pharmaceutical Secondary Standard; Certified Reference Material 4350-09-8 100MG $233 2022-05-15 Buy
    Sigma-Aldrich 399698 5-Hydroxy-L-tryptophan - CAS 895096 - Calbiochem Serotonin precursor. 4350-09-8 25G $466 2022-05-15 Buy
    Sigma-Aldrich 1329913 5-Hydroxy-L-tryptophan United States Pharmacopeia (USP) Reference Standard 4350-09-8 100mg $400 2022-05-15 Buy
    Product number Packaging Price Buy
    PHL80477 50MG $250 Buy
    107751 1g $42.7 Buy
    PHR2597 100MG $233 Buy
    399698 25G $466 Buy
    1329913 100mg $400 Buy

    L-5-Hydroxytryptophan Chemical Properties,Uses,Production

    Chemical Properties

    white to pale grey powder


    5-Hydroxy-L-Tryptophan is a hydroxylated metabolite of L-Tryptophan


    A labelled metabolite of Tryptophan


    5-Hydroxy-L-tryptophan has been used:

    • to inject experimental mice for serotonin detection
    • as a precursor of 5-hydroxytryptamine and injected in pregnant mice and neonatal rats for vital neutral red staining of lung slices
    • as a standard in citrate-acetate buffer for its use in high performance liquid chromatography (HPLC) analysis


    ChEBI: 5-hydroxy-L-tryptophan is the L-enantiomer of 5-hydroxytryptophan. It has a role as a human metabolite, a plant metabolite and a mouse metabolite. It is a 5-hydroxytryptophan, a hydroxy-L-tryptophan and a non-proteinogenic L-alpha-amino acid. It is an enantiomer of a 5-hydroxy-D-tryptophan. It is a tautomer of a 5-hydroxy-L-tryptophan zwitterion.

    General Description

    Colorless to pale pink crystals.

    Air & Water Reactions

    L-5-Hydroxytryptophan is sensitive to air. Slightly water soluble .

    Reactivity Profile

    L-5-Hydroxytryptophan reacts with bases. .

    Fire Hazard

    Flash point data for L-5-Hydroxytryptophan are not available, however, L-5-Hydroxytryptophan is probably combustible.

    Trade name

    Levothym (Promonta Lundbeck, Germany), Lévotonine (Panpharma, France), Oxyfan (Coli, Italy), Tript-OH (Sigma- Tai, Italy).

    Biochem/physiol Actions

    Hydroxylation of L-tryptophan occurs in the brain during serotonin synthesis. This is a step that controls the production of serotonin and also yields 5-hydroxy-l-tryptophan (5-HTP) as a metabolite. Thus, consumption 5-HTP, increases the serotonin level, which might result in depression, lack of sleep and severe headache.

    Purification Methods

    Likely impurities are 5-hydroxy-D-tryptophan and 5-benzyloxytryptophan. Crystallise 5-hydroxy-L-tryptophan under nitrogen from water by adding EtOH. Store it under nitrogen. Also dissolve it in the minimum volume of hot H2O (~0.7g in 4mL) under nitrogen (charcoal) and allowed it to crystallise at 5o. The picrolonate crystallises from H2O with m 184-186o(dec). [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p 2732-2737 1961, Morris & Armstrong J Org Chem 22 306 1957, Beilstein 22/14 V 278.]

    Synthesis of L-5-Hydroxytryptophan from 1H-Indole-3-propanamide, α-amino-5-hydroxy-, (αS)-

    L-5-Hydroxytryptophan Preparation Products And Raw materials

    Raw materials

    Preparation Products

    Global( 439)Suppliers
    Supplier Tel Email Country ProdList Advantage
    Jiangxi Chiyan Biopharmaceutical Technology Co.,Ltd.
    +undefined13970866816 info@zybiopharma.com China 246 58
    15202951039 jason@sgonekbio.com China 268 58
    Shanghai UCHEM Inc.
    +862156762820 +86-13564624040 sales@myuchem.com China 6076 58
    +8618058761490 info@gihichemicals.com China 50002 58
    Hebei Mojin Biotechnology Co., Ltd
    15028179902 +8615028179902 sales@hbmojin.com China 12241 58
    Firsky International Trade (Wuhan) Co., Ltd
    +8615387054039 admin@firsky-cn.com China 436 58
    Hebei Fengqiang Trading Co., LTD
    +8613373049370 kaia@hbfengqiang.com China 982 58
    Capot Chemical Co.,Ltd.
    571-85586718 +8613336195806 sales@capotchem.com China 29767 60
    Henan DaKen Chemical CO.,LTD.
    +86-0371-66670886 info@dakenchem.com China 14738 58
    Henan Tianfu Chemical Co.,Ltd.
    +86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21722 55

    View Lastest Price from L-5-Hydroxytryptophan manufacturers

    Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
    L-5-Hydroxytryptophan pictures 2023-11-28 L-5-Hydroxytryptophan
    US $1.00 / ASSAYS 1g 99.99%+ 20T Jinan Jianfeng Chemical Co., Ltd
    L-5-Hydroxytryptophan pictures 2023-10-26 L-5-Hydroxytryptophan
    US $18.00-206.00 / g 25g 0.99 100kg Shanghai UCHEM Inc.
    L-5-Hydroxytryptophan pictures 2023-10-08 L-5-Hydroxytryptophan
    US $30.00 / KG 1KG 99% 20T Firsky International Trade (Wuhan) Co., Ltd
    L-5-HYDROXYTRYPTOPHAN HYDRATE L-5-HYDROXYTRYPTOPHAN 2-AMINO-3-(5-HYDROXY-1H-INDOL-3-YL)PROPIONIC ACID (-)-5-HYDROXY-L-TRYPTOPHAN 5-HYDROXY-L-TRP-OH pretonine L-5-Hydroxytryptophan, 99% 5GR L-5-HTP, L-2-Amino-3-(5-hydroxyindolyl)propionic acid 5-Hydroxy-L-tryphophane 5-Hydroxy-L-tryptophan 98% (calc. on dried substance) 5-Hydroxy-L-tryptophan(5-HTP) 5-Hydroxy-L-tryptophan99% L-Trp(5-OH)-OH 5-Hydroxy-L-tryptophan, Free Acid L-Tryptophan, 5-hydroxy- l-2-amino-3-[3-(5-hydroxyindole)]propionic acid 5-HYDROXY-1-TRYTOPHAN 5-Hydroxyl-L-tryptophan. quietim 5-HYDROXY-L-TRYPTOPHAN 99,0 % min H-L-Trp(5-OH)-OH 5-HTP Griffonia Seed L-2-Amino-3-(5-hydroxyindolyl)propionic acid, L-5-HTP 5-HYDROXY-L-TRYPTOPHAN 99% 5-HTP HPLC L-2-Amino-3-(5-hydroxyindolyl)propionic acid L-5-HTP 5-HTP 5-Hydroxy-L-tryptophan, Dihydrate 5-HYDROXY-TRP-OH C5-HYDROXY-L-TRYPTOPHAN H-5-HYDROXY-TRP-OH H-TRP(5-OH)-OH (S)-2-AMINO-3-(5-HYDROXY-1H-INDOL-3-YL)-PROPIONIC ACID (2S)-2-Amino-3-(5-hydroxy-1H-indol-3-yl)propanoic acid Levothym L-5-Hydroxytryptophan,99% L-5-Hydroxytryptopha (S)-5-Hydroxytryptophan 5-Hydroxytryptophan(5-HTP,Oxitriptan) (S)-2-AMino-3-(5-hydroxy-1H-indol-3-yl)-propionic acid, C5-Hydroxy-L-tryptophan, 5-HTP, Oxitriptan 5-Hydroxy-L-tryptophan-d 3 L-5-Hydroxytryptophan, 99% 1GR L-oxitriptan L-5-Hydroxytryptophan USP/EP/BP N-Acetyltryptophan EP Impurity D laevo-oxitriptan 5-Hydroxy L-trpytophan, 99% TIANFU-CHEM CAS NO.4350-09-8 Polyurethane foams 5-Hydroxy-L-Tryptophan extrapure, 99% 5-Hydroxy-L-tryptophan (1329913) L-HTP Tryptophan Impurity 9(Tryptophan EP Impurity D) L-5-Hydroxytryptophan (Synonyms: L-5-HTP Ghana seed extract L-5-Hydroxytryptophan (L-5-HTP L-5-Hydroxytryptophan(Tryptophan EP Impurity D) HPLC>=98% 5-Hydroxy-L-tryptophan> (S)-2-Amino-3-(5-hydroxy-1H-indol-3 L-5-HTP
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