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N-Benzyl-4-piperidone

N-Benzyl-4-piperidone structure

CAS No.: 3612-20-2

Chemical Name:: N-Benzyl-4-piperidone

Synonyms: 1-BENZYLPIPERIDIN-4-ONE;1-BENZYL-4-PIPERIDONE;Benzyl piperidone;N-Benzylpiperidin-4-one;NSC 77933;-4-piperidone;N-BENZYLPIPERIDONE;1-Benzylpiperidone;BENZYLPIPERIDONE-4;Benzamide,7-bromo-

CBNumber:: CB8341198

Molecular Formula:: C12H15NO

Molecular Weight:: 189.25

MDL Number:: MFCD00006192

MOL File:: 3612-20-2.mol

MSDS File:: SDS

Last updated:2023-11-02 17:49:29

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N-Benzyl-4-piperidone Properties

Boiling point	134 °C7 mm Hg(lit.)
Density	1.021 g/mL at 25 °C(lit.)
vapor pressure	0.079-0.15Pa at 20-25℃
refractive index	n20/D 1.541(lit.)
Flash point	>230 °F
storage temp.	2-8°C
solubility	12g/l
form	Oily Liquid
pka	7.07±0.20(Predicted)
Specific Gravity	1.021
color	Clear colorless to straw
Water Solubility	12 g/L (20 ºC)
BRN	128556
LogP	2.1 at 20℃ and pH9
CAS DataBase Reference	3612-20-2(CAS DataBase Reference)
FDA UNII	399249PH5B
NIST Chemistry Reference	4-Piperidinone, 1-(phenylmethyl)-(3612-20-2)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319

Precautionary statements

P264-P270-P280-P301+P312-P302+P352-P305+P351+P338

Hazard Codes

Xi,Xn

Risk Statements

36/37/38-43-22-20/21/22

Safety Statements

26-36-37/39

WGK Germany

Hazard Note

Irritant

HS Code

29333999

NFPA 704

	2
2		0

N-Benzyl-4-piperidone price More Price(46)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	B29806	1-Benzyl-4-piperidone 99%	3612-20-2	25g	$40	2023-06-20	Buy
Sigma-Aldrich	B29806	1-Benzyl-4-piperidone 99%	3612-20-2	100g	$77	2023-06-20	Buy
TCI Chemical	B1027	1-Benzyl-4-piperidone >98.0%(GC)(T)	3612-20-2	25mL	$30	2023-06-20	Buy
TCI Chemical	B1027	1-Benzyl-4-piperidone >98.0%(GC)(T)	3612-20-2	500mL	$282	2023-06-20	Buy
Alfa Aesar	A12390	1-Benzyl-4-piperidone, 98+%	3612-20-2	25g	$31.9	2023-06-20	Buy

Product number	Packaging	Price	Buy
B29806	25g	$40	Buy
B29806	100g	$77	Buy
B1027	25mL	$30	Buy
B1027	500mL	$282	Buy
A12390	25g	$31.9	Buy

N-Benzyl-4-piperidone Chemical Properties,Uses,Production

Chemical Properties

Clear colorless to straw coloured oily liquid

Uses

1-Benzyl-4-piperidone is a pharmaceutical intermediate, it is used in penfluridol synthesis of bulk drugs.

Uses

A substituted piperidine as pesticide

Reactions

As an important organic compound, N-Benzyl-4-piperidone could be used to synthesize many organic compounds. There are four ways to synthesize 1-benzylpiperidine-4-carbaldehyde using it as the raw material. The first method involves the Wittig reaction of (methoxymethyl) triphenylphosphonium chloride with N-benzyl-4-piperidone, followed by hydrolysis of the resulting enol ether. In another method, trimethylsilyl diazomethane is condensed with N-benzyl-4-piperidone, followed by hydrolysis to obtain the final product. In a third route, N-benzyl-4-piperidone is treated with trimethyloxosulfonium iodide to produce the corresponding epoxide. The epoxide is then rearranged in the presence of magnesium bromide etherate, resulting in 1-benzylpiperidine-4-carbaldehyde with high yields. In 2007, a patent described the Darzens condensation of N-benzyl-4-piperidone with ethyl chloroacetate, followed by decarboxylation[1].

Purification Methods

If the physical properties show contamination, then dissolve it in the minimum volume of H2O, made strongly alkaline with aqueous KOH, extract it with toluene several times, dry the extract with K2CO3, filter, evaporate and distil the residue at high vacuum using a bath temperature of 160-190o, and redistil it. [Brookes & Walker J Chem Soc 3173 1957, Bolyard J Am Chem Soc 52 1030 1930.] The hydrochloride has m 159-161o (from Me2CO/Et2O), and the picrate has m 174-182o (from Me2CO/Et2O). [Grob & Brenneisen Helv Chim Acta 41 1184 1958, Beilstein 21/6 V 424.]

References

[1] Chavakula R, et al. Industrially Viable Preparation ofN-Benzyl-4-formylpiperidine, a Key Intermediate of Donepezil. Organic Preparations and Procedures International, 2013; 45: 168-170.

N-Benzyl-4-piperidone synthesis

Synthesis of N-Benzyl-4-piperidone from 4-oxopiperidinium chloride and Benzyl bromide

N-Benzyl-4-piperidone Preparation Products And Raw materials

Raw materials

Benzylamine Methyl propionate 4,4-Piperidinediol hydrochloride

Preparation Products

N-Boc-2-piperidone 4,5,6,7-TETRAHYDRO-2-METHYLFURO[3,2-C]PYRIDINE 1-BOC-4-HYDROXY-4-(HYDROXYMETHYL)-PIPERIDINE 4-(3-Trifuoromethyl)phenyl-4-piperidinol 1-BENZYL-4-HYDROXY-4-(3-TRIFLUOROTOLYL)PIPERIDINOL

1-Benzyl-4-hydroxypiperidine (1-BENZYLPIPERIDIN-4-YLIDENE)ACETIC ACID ETHYL ESTER 1H-Azepine-4-carboxylicacid,hexahydro-,methylester,(4S)-(9CI) 4-(1-Pyrrolidinyl)piperidine 1H-Azepine-4-carboxylicacid,hexahydro-,methylester,(4R)-(9CI)

2-Oxa-8-azaspiro[4.5]decane Methyl 1-benzyl-4-hydroxypiperidine-4-carboxylate 4-(2-Aminoethyl)-1-benzylpiperidine 4-(4-FLUORO-PHENYL)-PIPERIDIN-4-OL HYDROCHLORIDE 4-METHYLENEPIPERIDINE

TERT-BUTYL 1-OXA-4,9-DIAZASPIRO[5.5]UNDECANE-4-CARBOXYLATE

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N-Benzyl-4-piperidone Suppliers

Global( 575)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Anhui Dexinjia Biopharm Co., Ltd	+86-531-82375818 +8615064153060	alice@jndxj.com	China	302	58
ZHEJIANG JIUZHOU CHEM CO., LTD	+86-0576225566889 +86-13454675544	admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com	China	21622	58
Shanghai Dekang Medical Technology Co., LTD	+86-0086-1893110-2411 +8618931102411	1137059254@qq.com	China	9300	58
Hebei Endun Biological Technology Co. LTD	+86-8615932657220 +86-15932657220	sales05@hebeiendun.cn	China	300	58
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5948	58
Shandong Huisheng Import & Export Co., Ltd.	+86-13176845580 +86-13176845580	da@zhongda-biotech.com	China	248	58
Anhui Zhongda Biotechnology Co., Ltd	+8619956560829	justine@zhongda-biotech.com	China	300	58
Anhui Zhongda Biotechnology Co., Ltd	+8615689548120	linda@zhongda-biotech.com	China	204	58
Anhui Ruihan Technology Co., Ltd	+8617756083858	daisy@anhuiruihan.com	China	994	58
Frapp's ChemicalNFTZ Co., Ltd.	+86 (576) 8169-6106	sales@frappschem.com	China	885	50

Supplier	Advantage
Anhui Dexinjia Biopharm Co., Ltd	58
ZHEJIANG JIUZHOU CHEM CO., LTD	58
Shanghai Dekang Medical Technology Co., LTD	58
Hebei Endun Biological Technology Co. LTD	58
Hebei Yanxi Chemical Co., Ltd.	58
Shandong Huisheng Import & Export Co., Ltd.	58
Anhui Zhongda Biotechnology Co., Ltd	58
Anhui Zhongda Biotechnology Co., Ltd	58
Anhui Ruihan Technology Co., Ltd	58
Frapp's ChemicalNFTZ Co., Ltd.	50

View Lastest Price from N-Benzyl-4-piperidone manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2023-11-21	N-Benzyl-4-piperidone 3612-20-2	US $1.00 / g	1000g	99%	20ton/month	Wuhan Aoliqisi New Material Technology Co., Ltd.
2023-11-03	N-Benzyl-4-piperidone 3612-20-2	US $0.00-0.00 / g	1g	99%	100000tons	Anhui Zhongda Biotechnology Co., Ltd
2023-10-20	N-Benzyl-4-piperidone 3612-20-2	US $90.00-70.00 / kg	1kg	99%	10000/month	Anhui Zhongda Biotechnology Co., Ltd

N-Benzyl-4-piperidone
3612-20-2
US $1.00 / g
99%
Wuhan Aoliqisi New Material Technology Co., Ltd.

N-Benzyl-4-piperidone
3612-20-2
US $0.00-0.00 / g
99%
Anhui Zhongda Biotechnology Co., Ltd

N-Benzyl-4-piperidone
3612-20-2
US $90.00-70.00 / kg
99%
Anhui Zhongda Biotechnology Co., Ltd

N-Benzyl-4-piperidone Spectrum

N-Benzyl-4-piperidone(3612-20-2)MS N-Benzyl-4-piperidone(3612-20-2)¹HNMR N-Benzyl-4-piperidone(3612-20-2)¹³CNMR N-Benzyl-4-piperidone(3612-20-2)IR1 N-Benzyl-4-piperidone(3612-20-2)Raman

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NSC 77933 1-BENZYL-4-PIPERIDINONE FOR SYNTHESIS [(4-Oxopiperidin-1-yl)methyl]benzene, 1-Benzyl-4-oxopiperidine N- benzylpiperidineketone 1-Benzyl-4-piperidone, 99%, 99% N - benzyl - 4 - piperidine ketone (3612-20-2) N-BENZYL-4-PIPERIDONE 1-Benzylpiperidone N-BENZYLPIPERIDONE 1-Benzyl-4-Pipridine 1-Benzylpiperid-4-one 1-Benzyl-4-Piperidone/1-Benzylpiperidone N-Benzyl-4-Piperidone99% 1-Benzyl-4-piperidone, 98+% 1-Benzyl-4-piperidine 1-BENZYL-4-PIPERIDONE(N-BENZYL-4-PIPERIDONE) 1-Benzylpiperidin-4-one 96% 1-(Phenylmethyl)piperidin-4-one N-Benzyl-4-oxopiperidine 1-Benzyl-1,2,5,6-tetrahydropyridine-4(3H)-one 4-Piperidone, 1-benzyl- 4-Piperidone,1-benzyl- N-Benzyl-4-piperidinone N-Benzyl-4-piperidon N-Benzylpiperidinone LABOTEST-BB LT00232987 BENZYL-4-PIPERIDONE BENZYLPIPERIDONE-4 1-BENZYL-4-PIPERIDINONE 1-BENZYL-4-OXOPIPERIDINE 1-(PHENYLMETHYL)-4-PIPERIDINONE 1-(PHENYLMETHYL)-4-PIPERIDONE (4-Oxopiperidin-4-yl)methylbenzene 4-PIPERIDINONE, 1-(PHENYLMETHYL)- N - benzyl - 4 - piperidine ketone (3612- Irinotecan Impurity 30 N-BENZYL-4-PIPERIDONEBROMIDE 1-Benzyl-4-piperidone > -4-piperidone N-Benzyl-4-piperidone ISO 9001：2015 REACH N-benzy-4-piperdone N-benzy-4-piperdone powder 1-Benzy-4-piperidone(NBP) Benzyl piperidone N-Benzylpiperidin-4-one 1-BENZYL-4-PIPERIDONE 1-BENZYLPIPERIDIN-4-ONE Benzamide,7-bromo- RSYY（Lifitegrast)-13 1-Benzy-4-piperidone 3612-20-2 3612-20-3 KETONE Heterocyclic Building Blocks Piperidones Building Blocks Piperidines, Piperidones, Piperazines pharmacetical