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    ChemicalBook >> CAS DataBase List >>N-Benzyl-4-piperidone


    CAS No.
    Chemical Name:
    1-BENZYLPIPERIDIN-4-ONE;1-BENZYL-4-PIPERIDONE;Benzyl piperidone;N-Benzylpiperidin-4-one;NSC 77933;-4-piperidone;N-BENZYLPIPERIDONE;1-Benzylpiperidone;BENZYLPIPERIDONE-4;Benzamide,7-bromo-
    Molecular Formula:
    Molecular Weight:
    MDL Number:
    MOL File:
    MSDS File:
    Last updated:2023-11-02 17:49:29

    N-Benzyl-4-piperidone Properties

    Boiling point 134 °C7 mm Hg(lit.)
    Density 1.021 g/mL at 25 °C(lit.)
    vapor pressure 0.079-0.15Pa at 20-25℃
    refractive index n20/D 1.541(lit.)
    Flash point >230 °F
    storage temp. 2-8°C
    solubility 12g/l
    form Oily Liquid
    pka 7.07±0.20(Predicted)
    Specific Gravity 1.021
    color Clear colorless to straw
    Water Solubility 12 g/L (20 ºC)
    BRN 128556
    LogP 2.1 at 20℃ and pH9
    CAS DataBase Reference 3612-20-2(CAS DataBase Reference)
    FDA UNII 399249PH5B
    NIST Chemistry Reference 4-Piperidinone, 1-(phenylmethyl)-(3612-20-2)


    Risk and Safety Statements

    Symbol(GHS)  GHS hazard pictograms
    Signal word  Warning
    Hazard statements  H302-H315-H319
    Precautionary statements  P264-P270-P280-P301+P312-P302+P352-P305+P351+P338
    Hazard Codes  Xi,Xn
    Risk Statements  36/37/38-43-22-20/21/22
    Safety Statements  26-36-37/39
    WGK Germany  3
    Hazard Note  Irritant
    HS Code  29333999
    NFPA 704
    2 0

    N-Benzyl-4-piperidone price More Price(46)

    Manufacturer Product number Product description CAS number Packaging Price Updated Buy
    Sigma-Aldrich B29806 1-Benzyl-4-piperidone 99% 3612-20-2 25g $40 2023-06-20 Buy
    Sigma-Aldrich B29806 1-Benzyl-4-piperidone 99% 3612-20-2 100g $77 2023-06-20 Buy
    TCI Chemical B1027 1-Benzyl-4-piperidone >98.0%(GC)(T) 3612-20-2 25mL $30 2023-06-20 Buy
    TCI Chemical B1027 1-Benzyl-4-piperidone >98.0%(GC)(T) 3612-20-2 500mL $282 2023-06-20 Buy
    Alfa Aesar A12390 1-Benzyl-4-piperidone, 98+% 3612-20-2 25g $31.9 2023-06-20 Buy
    Product number Packaging Price Buy
    B29806 25g $40 Buy
    B29806 100g $77 Buy
    B1027 25mL $30 Buy
    B1027 500mL $282 Buy
    A12390 25g $31.9 Buy

    N-Benzyl-4-piperidone Chemical Properties,Uses,Production

    Chemical Properties

    Clear colorless to straw coloured oily liquid


    1-Benzyl-4-piperidone is a pharmaceutical intermediate, it is used in penfluridol synthesis of bulk drugs.


    A substituted piperidine as pesticide


    As an important organic compound, N-Benzyl-4-piperidone could be used to synthesize many organic compounds. There are four ways to synthesize 1-benzylpiperidine-4-carbaldehyde using it as the raw material. The first method involves the Wittig reaction of (methoxymethyl) triphenylphosphonium chloride with N-benzyl-4-piperidone, followed by hydrolysis of the resulting enol ether. In another method, trimethylsilyl diazomethane is condensed with N-benzyl-4-piperidone, followed by hydrolysis to obtain the final product. In a third route, N-benzyl-4-piperidone is treated with trimethyloxosulfonium iodide to produce the corresponding epoxide. The epoxide is then rearranged in the presence of magnesium bromide etherate, resulting in 1-benzylpiperidine-4-carbaldehyde with high yields. In 2007, a patent described the Darzens condensation of N-benzyl-4-piperidone with ethyl chloroacetate, followed by decarboxylation[1].

    Purification Methods

    If the physical properties show contamination, then dissolve it in the minimum volume of H2O, made strongly alkaline with aqueous KOH, extract it with toluene several times, dry the extract with K2CO3, filter, evaporate and distil the residue at high vacuum using a bath temperature of 160-190o, and redistil it. [Brookes & Walker J Chem Soc 3173 1957, Bolyard J Am Chem Soc 52 1030 1930.] The hydrochloride has m 159-161o (from Me2CO/Et2O), and the picrate has m 174-182o (from Me2CO/Et2O). [Grob & Brenneisen Helv Chim Acta 41 1184 1958, Beilstein 21/6 V 424.]


    [1] Chavakula R, et al. Industrially Viable Preparation ofN-Benzyl-4-formylpiperidine, a Key Intermediate of Donepezil. Organic Preparations and Procedures International, 2013; 45: 168-170.

    Synthesis of N-Benzyl-4-piperidone from 4-oxopiperidinium chloride and Benzyl bromide
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    View Lastest Price from N-Benzyl-4-piperidone manufacturers

    Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
    N-Benzyl-4-piperidone pictures 2023-11-21 N-Benzyl-4-piperidone
    US $1.00 / g 1000g 99% 20ton/month Wuhan Aoliqisi New Material Technology Co., Ltd.
    N-Benzyl-4-piperidone pictures 2023-11-03 N-Benzyl-4-piperidone
    US $0.00-0.00 / g 1g 99% 100000tons Anhui Zhongda Biotechnology Co., Ltd
    N-Benzyl-4-piperidone pictures 2023-10-20 N-Benzyl-4-piperidone
    US $90.00-70.00 / kg 1kg 99% 10000/month Anhui Zhongda Biotechnology Co., Ltd
    NSC 77933 1-BENZYL-4-PIPERIDINONE FOR SYNTHESIS [(4-Oxopiperidin-1-yl)methyl]benzene, 1-Benzyl-4-oxopiperidine N- benzylpiperidineketone 1-Benzyl-4-piperidone, 99%, 99% N - benzyl - 4 - piperidine ketone (3612-20-2) N-BENZYL-4-PIPERIDONE 1-Benzylpiperidone N-BENZYLPIPERIDONE 1-Benzyl-4-Pipridine 1-Benzylpiperid-4-one 1-Benzyl-4-Piperidone/1-Benzylpiperidone N-Benzyl-4-Piperidone99% 1-Benzyl-4-piperidone, 98+% 1-Benzyl-4-piperidine 1-BENZYL-4-PIPERIDONE(N-BENZYL-4-PIPERIDONE) 1-Benzylpiperidin-4-one 96% 1-(Phenylmethyl)piperidin-4-one N-Benzyl-4-oxopiperidine 1-Benzyl-1,2,5,6-tetrahydropyridine-4(3H)-one 4-Piperidone, 1-benzyl- 4-Piperidone,1-benzyl- N-Benzyl-4-piperidinone N-Benzyl-4-piperidon N-Benzylpiperidinone LABOTEST-BB LT00232987 BENZYL-4-PIPERIDONE BENZYLPIPERIDONE-4 1-BENZYL-4-PIPERIDINONE 1-BENZYL-4-OXOPIPERIDINE 1-(PHENYLMETHYL)-4-PIPERIDINONE 1-(PHENYLMETHYL)-4-PIPERIDONE (4-Oxopiperidin-4-yl)methylbenzene 4-PIPERIDINONE, 1-(PHENYLMETHYL)- N - benzyl - 4 - piperidine ketone (3612- Irinotecan Impurity 30 N-BENZYL-4-PIPERIDONEBROMIDE 1-Benzyl-4-piperidone > -4-piperidone N-Benzyl-4-piperidone ISO 9001:2015 REACH N-benzy-4-piperdone N-benzy-4-piperdone powder 1-Benzy-4-piperidone(NBP) Benzyl piperidone N-Benzylpiperidin-4-one 1-BENZYL-4-PIPERIDONE 1-BENZYLPIPERIDIN-4-ONE Benzamide,7-bromo- RSYY(Lifitegrast)-13 1-Benzy-4-piperidone 3612-20-2 3612-20-3 KETONE Heterocyclic Building Blocks Piperidones Building Blocks Piperidines, Piperidones, Piperazines pharmacetical
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