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2-Chloronicotinic acid

2-Chloronicotinic acid structure

CAS No.: 2942-59-8

Chemical Name:: 2-Chloronicotinic acid

Synonyms: 2-CHLOROPYRIDINE-3-CARBOXYLIC ACID;CHLORONICOTINIC ACID;2-CHLORO-3-PYRIDINECARBOXYLIC ACID;2CLNA;2-Chloronicoti;2 - chloro niacin;AKOS BBS-00004231;oronicotinic acid;TIMTEC-BB SBB004002;RARECHEM AL BO 0287

CBNumber:: CB7714896

Molecular Formula:: C6H4ClNO2

Molecular Weight:: 157.55

MDL Number:: MFCD00006236

MOL File:: 2942-59-8.mol

MSDS File:: SDS

Last updated:2023-10-10 20:13:16

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2-Chloronicotinic acid Properties

Melting point	176-178 °C (dec.)(lit.)
Boiling point	316.8±22.0 °C(Predicted)
Density	1.470±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO, Ethyl Acetate (Slightly)
pka	2.07±0.25(Predicted)
form	Powder
color	White to cream
BRN	119023
InChIKey	IBRSSZOHCGUTHI-UHFFFAOYSA-N
LogP	0.988
CAS DataBase Reference	2942-59-8(CAS DataBase Reference)
FDA UNII	93G386213F
EPA Substance Registry System	2-Chloronicotinic acid (2942-59-8)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

Hazard Codes

Risk Statements

36/37/38

Safety Statements

22-24/25-37/39-26-36

WGK Germany

TSCA

HazardClass

IRRITANT

HS Code

29333999

NFPA 704

	0
2		0

2-Chloronicotinic acid price More Price(47)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	150339	2-Chloropyridine-3-carboxylic acid 99%	2942-59-8	10g	$47.6	2023-06-20	Buy
Sigma-Aldrich	PHR2305	Flunixin Related Compound A Pharmaceutical Secondary Standard; Certified Reference Material	2942-59-8	50MG	$466	2022-05-15	Buy
Sigma-Aldrich	1274629	Flunixin Related Compound A United States Pharmacopeia (USP) Reference Standard	2942-59-8	15mg	$1370	2022-05-15	Buy
TCI Chemical	C1108	2-Chloronicotinic Acid >98.0%(HPLC)(T)	2942-59-8	25g	$21	2023-06-20	Buy
TCI Chemical	C1108	2-Chloronicotinic Acid >98.0%(HPLC)(T)	2942-59-8	250g	$99	2023-06-20	Buy

Product number	Packaging	Price	Buy
150339	10g	$47.6	Buy
PHR2305	50MG	$466	Buy
1274629	15mg	$1370	Buy
C1108	25g	$21	Buy
C1108	250g	$99	Buy

2-Chloronicotinic acid Chemical Properties,Uses,Production

Chemical Properties

white to cream powder. MP>175°C (decomposition), insoluble in water, soluble in organic solvents such as benzene and toluene.

Uses

2-Chloronicotinic Acid is used in the preparation of 4-thiazolidinone derivatives and Schiff bases displaying antimicrobial activity.

Application

2-Chloronicotinic acid is used in the synthesis of the anti-inflammatory and analgesic pralofen. It is an intermediate of the herbicides nicosulfuron and diflufenican. It is also used as pharmaceutical intermediates for the manufacture of mefenamic acid, niflumic acid, etc.

Preparation

Chloronicotinic acid was synthesized from nicotinic acid by oxidation by H2O2 and then chlorinationby POCl3 and PCl5 in a yield of 87.5%.
Synthesis of 2-chloronicotinic acid: Pour chlorine gas into the mixed solution of phosphorus oxychloride and phosphorus trichloride, control the temperature at about 60°C, until the remaining chlorine gas escapes, cool and add nicotinic acid N-oxide in batches, and heat the mixed solution. The reaction was carried out at 100-105°C for 1-1.5 h, and the reaction mixture was stirred for 30 min after the reaction mixture was transparent, and phosphorus oxychloride was removed under reduced pressure. The obtained residue was cooled to room temperature, and water was added to obtain the finished product of 2-chloronicotinic acid.

Definition

ChEBI: 2-Chloronicotinic acid is an aromatic carboxylic acid and a member of pyridines.

2-Chloronicotinic acid synthesis

Synthesis of 2-Chloronicotinic acid from 2-CHLORO-3-ETHYL PYRIDINE

2-Chloronicotinic acid Preparation Products And Raw materials

Raw materials

2-Chloro-3-picoline 3-Picoline Diisopropylamine 2-chloro-3-trichloromethylpyridine 2-Chloro-5-methylpyridine

Nicotinic acid N-oxide

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Preparation Products

Diflufenican 2-CHLOROPYRIDINE-3,4-DICARBOXYLIC ACID 2-(ETHYLTHIO)NICOTINIC ACID 2-Hydroxynicotinic acid 2-Aminonicotinic acid

METHYL 2-CHLORONICOTINATE 2-Methoxynicotinic acid 2-(2,3-dihydro-1,4-benzodioxin-6-yl)aminonicotinic acid

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2-Chloronicotinic acid Suppliers

Global( 890)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
CD Chemical Group Limited	+8615986615575	info@codchem.com	China	20356	58
Hubei Ipure Biology Co., Ltd	+8613367258412	ada@ipurechemical.com	China	10327	58
Nanjing Hengbei Chemicals Co., Ltd.	+86-25-58393656	sales@hengbeichem.cn	China	6856	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21722	55
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971 +86-17331933971	deasea125996@gmail.com	China	2506	58
Hebei Fengqiang Trading Co., LTD	+8613373049370	kaia@hbfengqiang.com	China	982	58
Anhui Ruihan Technology Co., Ltd	+8617756083858	daisy@anhuiruihan.com	China	994	58
Frapp's ChemicalNFTZ Co., Ltd.	+86 (576) 8169-6106	sales@frappschem.com	China	885	50
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29767	60
Henan DaKen Chemical CO.,LTD.	+86-0371-66670886	info@dakenchem.com	China	14738	58

Supplier	Advantage
CD Chemical Group Limited	58
Hubei Ipure Biology Co., Ltd	58
Nanjing Hengbei Chemicals Co., Ltd.	58
Henan Tianfu Chemical Co.,Ltd.	55
Henan Bao Enluo International TradeCo.，LTD	58
Hebei Fengqiang Trading Co., LTD	58
Anhui Ruihan Technology Co., Ltd	58
Frapp's ChemicalNFTZ Co., Ltd.	50
Capot Chemical Co.,Ltd.	60
Henan DaKen Chemical CO.,LTD.	58

View Lastest Price from 2-Chloronicotinic acid manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2023-11-28	2-Chloronicotinic acid 2942-59-8	US $0.00 / KG	1KG	99%	500mt	Jinan Finer Chemical Co., Ltd
2023-11-01	2-Chloronicotinic acid 2942-59-8	US $0.00 / kg	1kg	99.0% min	10tons/month	Hangzhou ICH Biofarm Co., Ltd
2023-10-10	2-Chloronicotinic acid 2942-59-8	US $0.00 / KG	1KG	0.99	5000kg	Hebei Yanxi Chemical Co., Ltd.

2-Chloronicotinic acid
2942-59-8
US $0.00 / KG
99%
Jinan Finer Chemical Co., Ltd

2-Chloronicotinic acid
2942-59-8
US $0.00 / kg
99.0% min
Hangzhou ICH Biofarm Co., Ltd

2-Chloronicotinic acid
2942-59-8
US $0.00 / KG
0.99
Hebei Yanxi Chemical Co., Ltd.

2-Chloronicotinic acid Spectrum

2-Chloronicotinic acid(2942-59-8)MS 2-Chloronicotinic acid(2942-59-8)¹HNMR 2-Chloronicotinic acid(2942-59-8)IR1 2-Chloronicotinic acid(2942-59-8)IR2 2-Chloronicotinic acid(2942-59-8)Raman

2942-59-8(2-Chloronicotinic acid)Related Search:

5-(4-BROMOPHENYL)-4-CHLORONICOTINIC ACID ETHYL ESTER 5-Bromo-2-chloronicotinic acid 97%,5-BROMO-2-CHLORONICOTINIC ACID Ethyl 2,6-dichloro-5-fluoro-pyridine-3-acetoacetate 2-CHLORONICOTINIC ACID METHYL ESTER Ethyl 2-(Chlorosulfonyl)acetate

2,5-Dichloronicotinic acid 2-CHLORO-3-[(([DI(2-THIENYL)METHYLENE]AMINO)OXY)CARBONYL]PYRIDINE (E)-2-(4-BROMOSTYRYL)-5-CHLORONICOTINIC ACID 5,6-Dichloronicotinic acid 2-CHLORO-3-(([(1,7,7-TRIMETHYLBICYCLO[2.2.1]HEPT-2-YLIDENE)AMINO]OXY)CARBONYL)PYRIDINE

6-[4-(aminocarbonyl)phenoxy]-5-chloronicotinic acid O-(2-CHLORONICOTINOYL) 5-(THIEN-2-YL)THIOPHEN-2-ALDOXIME Chromium picolinate 2-Bromo-5-chloronicotinic acid 6-[4-(tert-butoxycarbonyl)piperazino]-5-chloronicotinic acid

phosphoric acid 2-CHLORONICOTINOYL CHLORIDE = 2-CHLORONICOTINIC ACID CHLORIDE 2,4-Dichloropyridine-3-carboxylic acid Chloronicotinic Acid

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TIMTEC-BB SBB004002 2-chloro-3-pyridinecarboxylicaci 2-CHLOROPYRIDIN-3-CARBOXYLIC ACID 2CLNA 2-CHLORONICOTINIC ACID RARECHEM AL BO 0287 AKOS BBS-00004231 2-Chloronicotinic Aicd 2-Chloropyridine-3-carboxylic acid, 3-Carboxy-2-chloropyridine 2-chlorine nicotinic acid 2 - chloro niacin 2-Chloronicoti 2-Chloronicotinic acid 2-Chloro-3-pyridinecarboxylic acid 2-Chloropyridine-3-carboxylic acid 99% Flunixin Related CoMpound A 2-CHLORO-3-CARBOXYLPYRIDINE 2-Chloropyridine-3-carboxylic 2-Chloronicotinic acid 98% 2-Chloro Nicotinc Acid 3-Pyridinecarboxylic acid, 2-chloro- 2-ChloroNicotinicAcid,99%-100.5% 2-CHLORO-3-PYRIDINECARBOXYLIC ACID / 2-CHLORONICOTINIC ACID 2-CHLORONICOTINIC ACID 2-CHLOROPYRIDIN-3-CARBOXYLIC ACID 2-CHLORONITINICACID 2-Chloropyridine-3-carboxylic acid,2-Chloronicotinic acid 2-Chloronicotinic ac 2-chloro-3-picolinate Flunixin Meglumine Impurity 1（Flunixin Meglumine EP Impurity A） oronicotinic acid Flunixin Meglumine EP Impurity A 2-Chloronicotinic Acid > Niflumic acid impurity A CRS 2-Chlornicotinsaeure Niflumic Acid EP Impurity A Flunixin EP Impurity A 2 - nicotinic acid chloride Flunixin impurity AQ: What is Flunixin impurity A Q: What is the CAS Number of Flunixin impurity A Q: What is the storage condition of Flunixin impurity A Q: What are the applications of Flunixin impurity A Flunixin Related Compound A (2-Chloronicotinic acid) (1274629) 2-CHLORO-3-PYRIDINECARBOXYLIC ACID 2-CHLOROPYRIDINE-3-CARBOXYLIC ACID CHLORONICOTINIC ACID Flunixin USP Related Compound A 2-Chloronicotinic acidedione 2-Chloro Nicotinc Aci Flunixin Meglumine Impurity 3 2942-59-8 2492-59-8 Pyridines Halogenated Heterocycles Heterocyclic Building Blocks Halopyridines Chloropyridines Building Blocks ACID pyridine series blocks Carboxes Pyridines