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    ChemicalBook >> CAS DataBase List >>2,2'-Bipyridine


    CAS No.
    Chemical Name:
    Molecular Formula:
    Molecular Weight:
    MDL Number:
    MOL File:
    MSDS File:
    Last updated:2023-10-19 16:57:28

    2,2'-Bipyridine Properties

    Melting point 70-73 °C(lit.)
    Boiling point 273 °C(lit.)
    Density 1.1668 (rough estimate)
    vapor pressure 0.584Pa at 25℃
    refractive index 1.4820 (estimate)
    Flash point 121 °C
    storage temp. room temp
    solubility 5.5g/l
    form Crystalline Powder
    pka pK1:-0.52(+2);pK2:4.352(+1) (20°C)
    color White to almost white
    Odor Characteristic odour
    PH 7.5 (5g/l, H2O, 25℃)
    Water Solubility 5.5 g/L 22 ºC
    Merck 14,3347
    BRN 113089
    Stability Stable. Incompatible with strong oxidizing agents, most common metals. May be light sensitive.
    CAS DataBase Reference 366-18-7(CAS DataBase Reference)
    EWG's Food Scores 1
    FDA UNII 551W113ZEP
    NIST Chemistry Reference
    EPA Substance Registry System


    Risk and Safety Statements

    Symbol(GHS)  GHS hazard pictograms
    Signal word  Danger
    Hazard statements  H301+H311
    Precautionary statements  P264-P270-P280-P301+P310-P302+P352+P312-P361+P364
    Hazard Codes  T,Xi
    Risk Statements  25-36/37/38-20/21-23/24/25-21
    Safety Statements  36/37-45-36/37/39-26
    RIDADR  UN 2811 6.1/PG 3
    WGK Germany  3
    RTECS  DW1750000
    Hazard Note  Irritant
    TSCA  Yes
    HazardClass  6.1
    PackingGroup  III
    HS Code  29333999
    Toxicity LD50 i.p. in mice: 200 mg/kg (Grady)
    NFPA 704
    3 0

    2,2'-Bipyridine price More Price(64)

    Manufacturer Product number Product description CAS number Packaging Price Updated Buy
    Sigma-Aldrich 798533 2,2′-Bipyridyl anhydrous, free-flowing, Redi-Dri , ReagentPlus , 99% 366-18-7 50g $136 2023-06-20 Buy
    Sigma-Aldrich 798533 2,2′-Bipyridyl anhydrous, free-flowing, Redi-Dri , ReagentPlus , 99% 366-18-7 100g $152 2023-06-20 Buy
    Sigma-Aldrich 1.03098 2,2′-Bipyridine GR for analysis (reagent for iron(II) and molybdenum) ACS 366-18-7 5G $55.1 2022-05-15 Buy
    Sigma-Aldrich 1.03098 2,2′-Bipyridine GR for analysis (reagent for iron(II) and molybdenum) ACS 366-18-7 25g $185 2022-05-15 Buy
    TCI Chemical B0468 2,2'-Bipyridyl >99.0%(T) 366-18-7 25g $48 2023-06-20 Buy
    Product number Packaging Price Buy
    798533 50g $136 Buy
    798533 100g $152 Buy
    1.03098 5G $55.1 Buy
    1.03098 25g $185 Buy
    B0468 25g $48 Buy

    2,2'-Bipyridine Chemical Properties,Uses,Production

    Chemical Properties

    White to light red crystalline powder. Soluble in ethanol, ether, benzene, chloroform and petroleum ether, 1 part of this product is about 200 parts of water.


    A high-affinity chelator of iron. A reagent used for the determination of iron.


    2,2'-bipyridine acts as a bidentate chelating ligand which form complexes with transition metal ions and shows antifungal, antibacterial and antiviral activity. It is used for the colorimetric determination of iron as well as oxidation reduction indicators to confirm the presence of ferrous ion in soils. It forms complexes with ruthenium and platinum, exhibit intense luminescence, which may have practical applications. Copper(I) bipyridine complexes involved in the oxidation of alcohols under aerobic conditions.


    2,2'-bipyridine is synthesized by the reaction of pyridine with ferric chloride. Take 70g of anhydrous pyridine and mix with 13g of anhydrous ferric chloride, heat and react at 300℃ in a sealed tube for about 35h. After cooling, the reactant solidified into red-black crystals, the sealing tube was opened, and the red-black solution of the solid was washed out with a small amount of hot water. The oily impurities were removed by extraction with ether. After neutralization with sodium bicarbonate, excess pyridine was removed by heating with steam. The mixture was then made strongly basic, and the 2,2'-bipyridine was distilled off with steam.


    ChEBI: 2,2'-bipyridine is a bipyridine in which the two pyridine moieties are linked by a bond between positions C-2 and C-2'. It has a role as a ferroptosis inhibitor and a chelator.


    A large number of complexes of 2,2'-bipyridine have been described.It binds metals as a chelating ligand, forming a 5-membered chelate ring.

    Synthesis Reference(s)

    Journal of the American Chemical Society, 100, p. 5567, 1978 DOI: 10.1021/ja00485a053
    Synthesis, p. 564, 1986 DOI: 10.1055/s-1986-31705

    General Description

    2,2′-Bipyridyl, is a symmetrical bipyridine commonly used as a neutral ligand for complexation with metal ions. The molecule is planar with trans-conformation and crystallizes in the monoclinic crystal system.

    Biochem/physiol Actions

    Metalloprotease inhibitor, high-affinity chelator of iron; may inhibit Fe2+ containing enzymes at 10?8?M.

    Safety Profile

    Poison by ingestion,subcutaneous, and intraperitoneal routes. Experimentalteratogenic data. Questionable carcinogen withexperimental tumorigenic data. Mutation data reported.When heated to decomposition it emits toxic fumes ofNOx.


    2,2'-Bipyridine is a natural product found in Dichilus strictus, Dichilus gracilis, and other organisms with data available.

    Purification Methods

    2,2'-Bipyridyl crystallises from hexane, or EtOH, or (after charcoal treatment of a CHCl3 solution) from pet ether. Also, it precipitates from a concentrated solution in EtOH by addition of H2O. Dry it in a vacuum over P2O5. It can be further purified by chromatography on Al2O3 or by sublimation. UV (EtOH): at 280nm (log 4.13). max [Airoldi et al. J Chem Soc, Dalton Trans 1913 1986, Beilstein 23 H 199, 23/8 V 16.]

    Synthesis of 2,2'-Bipyridine from 2-PYRIDINECARBOXYLICACID CHLORIDE and Butylamine
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    View Lastest Price from 2,2'-Bipyridine manufacturers

    Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
    2,2' Dipyridyl pictures 2023-11-29 2,2' Dipyridyl
    US $20.00 / KG 1KG 99% 200 tons/ year Speranza Chemical Co., Ltd.
    2,2’-Bipyridine pictures 2023-10-19 2,2’-Bipyridine
    US $65.00-495.00 / g 1g 0.98 25kg Shanghai UCHEM Inc.
    2,2'-Bipyridine pictures 2023-09-12 2,2'-Bipyridine
    US $100.00 / bag 1bag 99 5000 Hebei Fengqiang Trading Co., LTD
    2,2'-Bipyridine, ACS, 98.0% min. 2,2-Bipyridyl (2,2-Bipyridine) 2,2'-Bipyridyl ReagentPlus(R), >=99% 2,2'-Bipyridyl Vetec(TM) reagent grade, 98% 2,2'-Bipyridine GR for analysis (reagent for iron(II) and molybdenum) ACS 2,2'-Dipyridyl≥ 99.5% (GC) ,’-Dipyridyl 2,2’-bipyridin CI-588 'LGC' (1607) 2,2'-DIPYRIDYL 2,2'-BIPYRIDINE A,A'-DIPYRIDYL ALPHA, ALPHA'-BIPYRIDINE ALPHA, ALPHA'-BIPYRIDYL ALPHA,ALPHA'-DIPYRIDYL 2,2-Dipyridyl (2,2-bipyridine) 2,2-Dipyridyl 99.5+ % for analysis BipyridineBIPYwhiteoffwhitextl 2,2'Bipyridinyl 2,2'-BIPYRIDYL, REDOX INDICATOR 2,2'-DIPYRIDYL, REAGENTPLUS, >=99% 2,2'-BIPYRIDINE PESTANAL 2,2,-Dipyridyl99+% 2, 2- DIPYRIDYL GR 2-2-BIPYRIDYL GR (2,2-Dipyridyl) 2,2'-Bipyridyl,99% 2,2'-BIPYRIDINE, REAG. 2,2'-BIPYRIDINE REAGENT (ACS) 2,2bipyridine, Bipyridine, Alpha, alphabipyridine, Alpha, alphabipyridyl, 2,2bipyridyl, CI-588, Alpha, alphadipyridyl, 2,2dipyridyl 2,2'-Bipyridine,99+%BIPY 2,2''-BIPYRIDINE BIPY 2,2''-DIPYRIDINE / 2,2''-DIPYRIDYL 2.2-BIPHENYL 99% 2,2''-BIPYRIDYL, GR 99+% 2,2'-Bipyridine, 99+% 2,2'-BIPYRIDINE (2,2'-Bipyridyl) 2'-Bipyridine 2,2-Dipyridyl 99+%, White Crystalline Powder, Reagent Grade α,α'-Dipyridyl, 2,2'-Dipyridyl 2,2'-BIPYRIDINE GR FOR ANALYSIS (REAGENT 2,2'-Bipyridine, ACS, 98% AA-DP alpha,alpha’-dwupirydylu alpha,alpha'-Dipyridine 2,2-Bipyridine, Reagent BIPYRIDINE(2,2'-) 2,2'-Bipyridin 2,2'-Dipyridine 2, 2 - al pyridine 2,2′-Bipyridyl,anhydrous, free-flowing 2,6'-Bipyridine 2,2'-Dipyridyl p.a. -Hydroxyphenyl)-2-butanone-d5 Oxime -Bipyridyl, 2,3&rsquo Isonicoteine (2,3&rsquo Anabaseine (3,4,5,6-Tetrahydro-2,3&rsquo B**2 2'-BIPYRIDYL
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