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    ChemicalBook >> CAS DataBase List >>6-Chloroguanine


    CAS No.
    Chemical Name:
    2-AMINO-6-CHLOROPURINE;6-Chloro-7H-purin-2-amine;2-amino-6-chloro-purin;6-CHLORO-2-AMINOPURINE;9H-PURIN-2-AMINE, 6-CHLORO-;2-AMINO-6-CHLOROPURINE (2A6ClP);AURORA KA-689;6-CHLOROGUANINE;TIMTEC-BB SBB003863;2-AMino-6-chlorpurin
    Molecular Formula:
    Molecular Weight:
    MDL Number:
    MOL File:
    MSDS File:
    Last updated:2023-08-01 14:32:22

    6-Chloroguanine Properties

    Melting point >300 °C (lit.)
    Boiling point 279.76°C (rough estimate)
    Density 1.4937 (rough estimate)
    refractive index 1.6110 (estimate)
    storage temp. 2-8°C
    solubility Solubility in 1mol/L NaOH
    form Powder
    pka 6.65±0.20(Predicted)
    color White to yellow
    Water Solubility 1.7 g/L (20 ºC)
    BRN 9626
    InChI InChI=1S/C5H4ClN5/c6-3-2-4(9-1-8-2)11-5(7)10-3/h1H,(H3,7,8,9,10,11)
    SMILES N1C2C(=NC(N)=NC=2Cl)NC=1
    CAS DataBase Reference 10310-21-1(CAS DataBase Reference)
    EWG's Food Scores 1
    FDA UNII 83V03P835E
    EPA Substance Registry System 6-Chloro-2-aminopurine (10310-21-1)


    Risk and Safety Statements

    Symbol(GHS)  GHS hazard pictograms
    Signal word  Warning
    Hazard statements  H315-H319-H335
    Precautionary statements  P201-P202-P261-P264b-P271-P280i-P302+P352-P304+P340-P305+P351+P338-P308+P313-P332+P313-P362+P364-P403+P233-P501c
    Hazard Codes  Xi,Xn
    Risk Statements  20/21/22-36/37/38
    Safety Statements  22-24/25-36-26
    WGK Germany  3
    RTECS  UO7502000
    Hazard Note  Irritant/Keep Cold
    HazardClass  IRRITANT, KEEP COLD
    HS Code  29339900
    NFPA 704
    2 0

    6-Chloroguanine price More Price(53)

    Manufacturer Product number Product description CAS number Packaging Price Updated Buy
    Sigma-Aldrich 109789 2-Amino-6-chloropurine ≥99% 10310-21-1 1g $25 2023-06-20 Buy
    Sigma-Aldrich 109789 2-Amino-6-chloropurine ≥99% 10310-21-1 5g $50 2023-06-20 Buy
    Sigma-Aldrich PHR2861 Famciclovir Related Compound F pharmaceutical secondary standard, certified reference material 10310-21-1 50MG $424 2022-05-15 Buy
    TCI Chemical A1407 2-Amino-6-chloropurine >98.0%(HPLC)(T) 10310-21-1 1g $34 2023-06-20 Buy
    TCI Chemical A1407 2-Amino-6-chloropurine >98.0%(HPLC)(T) 10310-21-1 5g $101 2023-06-20 Buy
    Product number Packaging Price Buy
    109789 1g $25 Buy
    109789 5g $50 Buy
    PHR2861 50MG $424 Buy
    A1407 1g $34 Buy
    A1407 5g $101 Buy

    6-Chloroguanine Chemical Properties,Uses,Production


    6-Chloroguanine, also be known as 2-Amino-6-chloropurine may be used in the enzymatic synthesis of 2′-deoxyguanosine, 9-alkyl purines (R)and (S)-N(2-phosphonomethoxypropyl) derivatives of purine and pyrimidine bases. It is also useful during the synthesis of guanine.


    2-Amino-6-chloropurine is a precursor in the synthesis of nucleoside analogs with antiviral activity against Epstein-Barr virus (EBV) and human herpes virus 6 (HHV-6).

    Chemical Properties

    white to light yellow crystal powder


    2-Amino-6-chloropurine may be used:

    • in the enzymatic synthesis of 2′-deoxyguanosine
    • in the synthesis of 9-alkyl purines
    • in the synthesis of (R)- and (S)-N-(2-phosphonomethoxypropyl) derivatives of purine and pyrimidine bases


    2-Amino-6-chloropurine finds its uses in the enzymatic synthesis of 2?-deoxyguanosine, 9-alkyl purines and (R)- and (S)-N-(2-phosphonomethoxypropyl) derivatives of purine and pyrimidine bases.


    ChEBI: 6-chloroguanine is an organochlorine compound that is 7H-purin-2-amine substituted by a chloro group at position 6. It is a member of 2-aminopurines and an organochlorine compound.

    General Description

    2-Amino-6-chloropurine is a 6-substituted purine. Tautomeric purine forms of 2-amino-6-chloropurine were investigated by vibrational spectroscopy and quantum chemical method.


    Preparation of 2-amino-6-chloropurine:
    Diacetyl guanine (8.0g, 0.034 moles), triethyimethylammonium chloride (15.45g, 0.102 moles), and triethylamine (4.74 mis, 0.034 moles) were heated together with stirring in acetonitrile (70mls) to 50°C. Phosphorus oxychioride (6.34 mis, 0.068 moles) was then added and stirring continued for 4 hours. The reaction mixture was cooled and then added to aqueous sodium hydroxide solution (20g in 300mls water). The reaction mixture was heated to 80°C for 2 hours and then the volume made up to 300 mis with water. The mixture was cooled to 25°C and the pH adjuster to 7 using 10% hydrochloric acid. The resulting slurry was stirred for fifteen minutes and the product filtered off and washed with water 30 mis and then dried at 80°C under vacuum to give a cream/off white coloured product, 2-amino-6-chioropurine 4.69 g (74.6% yield).

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    View Lastest Price from 6-Chloroguanine manufacturers

    Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
    6-Chloroguanine pictures 2023-11-29 6-Chloroguanine
    US $0.00 / Kg/Drum 100g/Bag 99% 100mt/year Jinan Finer Chemical Co., Ltd
    6-Chloroguanine pictures 2023-08-07 6-Chloroguanine
    US $0.00-0.00 / kg 1kg 98% 500kg per month Yunbio Tech Co.,Ltd.
    6-Chloroguanine pictures 2023-08-02 6-Chloroguanine
    US $0.00 / KG 1KG 99% 50000KG/month Hebei Mojin Biotechnology Co., Ltd
    • 6-Chloroguanine pictures
    • 6-Chloroguanine
    • US $0.00 / Kg/Drum
    • 99%
    • Jinan Finer Chemical Co., Ltd
    • 6-Chloroguanine pictures
    • 6-Chloroguanine
    • US $0.00 / KG
    • 99%
    • Hebei Mojin Biotechnology Co., Ltd
    AURORA KA-689 6-CHLORO-9H-PURIN-2-YLAMINE 6-CHLOROGUANINE 6-Chloro-7H-purin-2-ylamine TIMTEC-BB SBB003863 6-Chloro-2-purinamine 6-Chloro-7H-purine-2-amine 2-Amino-6-chloropuri 6-chloro-9H-purin-2-amine(SALTDATA: FREE) 2-aMino-6-cyanopurine 2-AMino-9H-purine-6-carbonitrile 2-AMino-6-chlorpurin FaMciclovir Related CoMpound F 2-AMino-6-chloropurine, 98+% 2 - aMino - 6 - chlorine purine Famciclovir Related Compound F (25 mg) (2-Amino-6-chloropurine) 1H-Purin-2-amine, 6-chloro- (9CI) 2-Amino-6-chlorpurine Purine, 2-amino-6-chloro- 6-chloro-1h-purin-2-amin 6-chloro-1h-purin-2-amine FAMCICLOVIR INTERMEDIATES 9-(4-acetoxy-3-acetoxymethylbut-1-y)-2-amino-6-chloro purine 2-Amino-6-chloro-9H-purine 6-CHLOROGUANINE CRYSTALLINE 2-Amino-6-Chloropurine(6-Chloroguanine) 1H-Purin-2-amine, 6-chloro- 2-Amino-6-chloro-9H-purine 99% 6-CHLOROGUANINE extrapure 4-Chloro-1,3,5,7-tetraaza-1H-indene-6-amine Clofarabine Impurity 3 2-Amino-6-chloropurine > 2-Amino-6-Chloro-Purin,>98% Famciclovir USP RC F 6-Chloroguanine USP/EP/BP Famciclovir Related Compound F (2-Amino-6-chloropurine) (1269141) 2-amino-6-chloro-purin 2-AMINO-6-CHLOROPURINE 6-CHLORO-2-AMINOPURINE 9H-PURIN-2-AMINE, 6-CHLORO- 6-Chloro-7H-purin-2-amine 2-AMINO-6-CHLOROPURINE (2A6ClP) Famciclovir USP Related Compound F 2-Amino-6-c2-Amino-6-chloropurinehloropurine Famciclovir Related Compound F (2-Amino-6-chloropurine) 10310-21-1 10310-21-2 233-686-7 C5H4CIN5 C5H4ClN2 Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks Purines Biochemistry Nucleobases and their analogs Nucleosides, Nucleotides & Related Reagents Nucleic acids Bases & Related Reagents
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