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1,1'-Carbonyldiimidazole

1,1'-Carbonyldiimidazole structure

CAS No.: 530-62-1

Chemical Name:: 1,1'-Carbonyldiimidazole

Synonyms: CDI;CARBONYLDIIMIDAZOLE;1,1'-CARBONYLDIIMIDAZOLE (CDI);DI(1H-IMIDAZOL-1-YL)METHANONE;N,N-CARBONYLDIIMIDAZOLE;Diimidazolyl ketone;1,1-CARBONYL DIIMIDAZOLE;5% Pd-BaSO4;CARBODIIMIDAZOLE;Di-imidazol-1-yl-methanone

CBNumber:: CB0215374

Molecular Formula:: C7H6N4O

Molecular Weight:: 162.15

MDL Number:: MFCD00005286

MOL File:: 530-62-1.mol

MSDS File:: SDS

Last updated:2023-10-31 16:47:27

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1,1'-Carbonyldiimidazole Properties

Melting point	117-122 °C(lit.)
Boiling point	288.83°C (rough estimate)
Density	1.303 g/mL at 25 °C
vapor pressure	0.006-0.012Pa at 20-25℃
refractive index	n20/D1.434
storage temp.	2-8°C
solubility	Soluble in dimethylformamide.
form	Crystalline Powder
pka	2.90±0.10(Predicted)
color	White to light cream
PH	7.7 (50g/l, H2O, 20℃)
PH Range	7.7 at 50 g/l
Water Solubility	Insoluble in water
Sensitive	Moisture Sensitive
Merck	14,1819
BRN	6826
Stability	Stable, but moisture-sensitive. Incompatible with acids, strong oxidizing agents, water.
InChIKey	PFKFTWBEEFSNDU-UHFFFAOYSA-N
CAS DataBase Reference	530-62-1(CAS DataBase Reference)
FDA UNII	63A10X1FSP
EPA Substance Registry System	1H-Imidazole, 1,1'-carbonylbis- (530-62-1)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS07,GHS08

Signal word

Danger

Hazard statements

H302-H314-H360D

Precautionary statements

P260-P280-P301+P312-P303+P361+P353-P304+P340+P310-P305+P351+P338

Hazard Codes

C,Xi,Xn

Risk Statements

22-34-36/37/38-40-36/38

Safety Statements

26-36/37/39-45-37/39-27-36/37

RIDADR

UN 3263 8/PG 2

WGK Germany

10-21

Hazard Note

Harmful/Corrosive/Moisture Sensitive

TSCA

HazardClass

PackingGroup

III

HS Code

29332990

Toxicity

LD50 orally in Rabbit: 1071 mg/kg

NFPA 704

	1
3		1

1,1'-Carbonyldiimidazole price More Price(68)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	8.02301	1,1′-Carbonyldiimidazole for synthesis	530-62-1	2G	$31.1	2023-06-20	Buy
Sigma-Aldrich	8.51054	CDI 1,1′-Carbonyldiimidazole Novabiochem?	530-62-1	25g	$163	2023-06-20	Buy
Sigma-Aldrich	8.02301	1,1′-Carbonyldiimidazole for synthesis	530-62-1	5G	$32.2	2023-06-20	Buy
Sigma-Aldrich	8.51054	CDI 1,1′-Carbonyldiimidazole Novabiochem?	530-62-1	100g	$486	2023-06-20	Buy
Sigma-Aldrich	8.02301	1,1′-Carbonyldiimidazole for synthesis	530-62-1	25G	$117	2023-06-20	Buy

Product number	Packaging	Price	Buy
8.02301	2G	$31.1	Buy
8.51054	25g	$163	Buy
8.02301	5G	$32.2	Buy
8.51054	100g	$486	Buy
8.02301	25G	$117	Buy

1,1'-Carbonyldiimidazole Chemical Properties,Uses,Production

Chemical Properties

The substance appears as a white to slightly pale-yellow crystalline powder with a melting point range of 115.5-116°C. It exhibits poor solubility in water, while displaying solubility in alcohol and ether.

Uses

CDI, also known as 1,1'-carbonyldiimidazole, is a commonly used peptide coupling reagent in the synthesis of peptides and nucleoside triphosphates. It usually contains approximately 10% imidazole and reacts rapidly with carboxylic acids to produce acyl imidazoles. Later, it readily reacts with amines to create amides. In addition, CDI is useful in converting alcohols and amines into a range of chemical compounds, including carbamates, esters, and ureas.

Application

Peptide coupling reagent1,1'-Carbonyldiimidazole acts as a coupling reagent and utilized for coupling of amino acids in order to prepare peptide in organic synthesis. It is also used in the preparation of beta-keto sulfones, sulfoxides and beta-enamino acid derivatives. It is used to convert alcohols and amines into carbamates, esters, and ureas. It is involved in the preparation of formylized imidazole by reaction with formic acid. Further, it is used in the synthesis of dipolar polyamides compounds. In addition to this, it is considered as an equivalent of phosgene and used to prepare asymmetric bis alkyl carbonate.

Preparation

1,1'-Carbonyldiimidazole has been prepared by the reaction of imidazole and phosgene in anhydrous benzene and anhydrous tetrahydrofuran. It has also been obtained by the reaction of 1-(trimethylsilyl)imidazole and phosgene in anhydrous benzene, but that method offers no advantages that justify the more extensive preparative effort required.
DOI: 10.15227/orgsyn.048.0044

General Description

1,1′-Carbonyldiimidazole (N,N′-carbonyldiimidazole) is a versatile peptide-forming reagent.

Purification Methods

Crystallise it from *benzene or tetrahydrofuran in a dry-box and store it dry. [Hearn Methods Enzymol 135 102 1987, Beilstein 23/4 V 245.]

Precautions

1,1'-Carbonyldiimidazole is incompatible with oxidizing agents and strong acids and should not be stored or handled near them. Store in a refrigerator, under inert gas and protected from moisture. This substance is heat sensitive and moisture sensitive.

1,1'-Carbonyldiimidazole synthesis

Synthesis of 1,1'-Carbonyldiimidazole from Triphosgene and N-(Trimethylsilyl)imidazole

1,1'-Carbonyldiimidazole Preparation Products And Raw materials

Raw materials

Imidazole N-(Trimethylsilyl)imidazole PHOSGENE Benzene

Preparation Products

2-(Boc-aminomethyl)-piperidine 3-oxo-3-phenyl-propanamide 5-(Pyridin-3-yl)-1H-pyrazole-3-carboxamide ,97% 3-Cyanomethylthiophene 4-AMINOMETHYL-BENZAMIDE

2,8-DICHLOROPYRIMIDO[5,4-D]PYRIMIDINE Progabide 2-AMINO-5-BROMOBENZAMIDE 2-Ethylpiperazine 6-FLUORO-1H-PYRAZOLO[3,4-B]PYRIDINE-3-CARBONITRILE

Pazufloxacin 5-BROMOTHIOPHENE-2-CARBONITRILE N-Heptafluorobutyrylimidazole 4-(Boc-Aminomethyl)piperidine 8-METHOXY-2-OXO-2H-CHROMENE-3-CARBOXYLIC ACID AMIDE

2-chloro-5-cyanopyridine 7-HYDROXY-2-OXO-2H-CHROMENE-3-CARBOXYLIC ACID AMIDE 1-Boc-2-Methylpiperazine 3-(1H-INDOL-3-YL)-1-PROPANAMINE 1-(4-ACETYLPIPERIDINO)ETHAN-1-ONE

5-BROMO-2-BENZOXAZOLINONE 97 isoglutamine 3-BROMOTHIOPHENE-2-CARBOXAMIDE 1-Boc-4-(aminomethyl)piperidine 2,3-diaminonaphthalene

4-N-BOC-Aminopiperidine 5-AMINO-3-PYRIDINECARBONITRILE 4-Cyanopiperidine 1,3-THIAZOLIDIN-2-ONE

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1,1'-Carbonyldiimidazole Suppliers

Global( 1031)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Baynoe Chem (Suzhou) Co., Ltd.	+86-512 65869404 +86-18934593683	sales06@baynoe.com	China	292	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24788	58
Shandong Believe Chemical PTE.LTD	+86-18553607090 +8618553607090	1093908296@qq.com	China	1685	58
CD Chemical Group Limited	+8615986615575	info@codchem.com	China	20356	58
BTC pharm India	+918790379245	banny.janga@btcpharm.com	India	1268	58
Changzhou Zechong Biopharma Co., Ltd.	+undefined18621330623	sales@zechongchem.com	China	28	58
HangYu Chemical Co.,Ltd	+86-0533-2185556 +8618560943802	Mandy@hangyuchemical.com	China	10903	58
Anhui Ruihan Technology Co., Ltd	+8617756083858	daisy@anhuiruihan.com	China	994	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29767	60
Henan DaKen Chemical CO.,LTD.	+86-0371-66670886	info@dakenchem.com	China	14736	58

Supplier	Advantage
Baynoe Chem (Suzhou) Co., Ltd.	58
LEAP CHEM CO., LTD.	58
Shandong Believe Chemical PTE.LTD	58
CD Chemical Group Limited	58
BTC pharm India	58
Changzhou Zechong Biopharma Co., Ltd.	58
HangYu Chemical Co.,Ltd	58
Anhui Ruihan Technology Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Henan DaKen Chemical CO.,LTD.	58

1,1'-Carbonyldiimidazole:Application and Preparation
1,1′-carbonyldiimidazole (CDI) is a white crystalline solid, and is often used for the coupling of amino acids for peptide syn....
Mar 29，2023

What is 1,1'-Carbonyldiimidazole?
1,1'-Carbonyldiimidazole (CDI) is an organic compound with the molecular formula (C3H3N2) 2CO. It is a white crystalline solid....
Jan 2，2020

View Lastest Price from 1,1'-Carbonyldiimidazole manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2023-11-29	1,1'-Carbonyldiimidazole 530-62-1	US $42.00-38.00 / kilograms	10kilograms	99%	100tons	Hebei Dangtong Import and export Co LTD
2023-11-29	1,1'-Carbonyldiimidazole 530-62-1	US $5.00 / kg	1kg	99%	200mt	Jinan Finer Chemical Co., Ltd
2023-11-24	1,1'-Carbonyldiimidazole 530-62-1	US $200.00-170.00 / KG	1KG	99.9%	20 tons	Hong Kong Excellence Biotechnology Co., Ltd.

1,1'-Carbonyldiimidazole
530-62-1
US $42.00-38.00 / kilograms
99%
Hebei Dangtong Import and export Co LTD

1,1'-Carbonyldiimidazole
530-62-1
US $5.00 / kg
99%
Jinan Finer Chemical Co., Ltd

1,1'-Carbonyldiimidazole
530-62-1
US $200.00-170.00 / KG
99.9%
Hong Kong Excellence Biotechnology Co., Ltd.

1,1'-Carbonyldiimidazole Spectrum

1,1'-Carbonyldiimidazole(530-62-1)MS 1,1'-Carbonyldiimidazole(530-62-1)¹HNMR 1,1'-Carbonyldiimidazole(530-62-1)¹³CNMR 1,1'-Carbonyldiimidazole(530-62-1)IR1 1,1'-Carbonyldiimidazole(530-62-1)Raman

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LABOTEST-BB LT00233203 IM2 C O (DIIMIDAZOL-1-YL)KETONE AKOS BBS-00004316 RARECHEM AK HZ 0060 1,1'-CARBONYLBIS-1H-IMIDAZOLE 1.1'-CARBONYL-BIS-IMIDAZOLE 1,1'-CARBONYLDIIMIDAZOLE 1H-IMIDAZOLE, 1,1'-CARBONYLBIS- 1,1’-carbonylbis-1h-imidazol 1,1’-Carbonyldiimidazol 1,1'-Carbonylbis-1H-imidazole [Coupling Agent for Peptides Synthesis] 1,1'-Carbonyldiimidazole [Coupling Agent for Peptides Synthesis] 1,1'-Carbonyldi(1H-imidazole) Bis(1H-imidazol-1-yl) ketone Bis(1-imidazolyl) ketone carbonyl-1,1’-bis-1H-diimidazole 1,1'-Carbonyldiimidazole,97% 1’-Carbonyldiimidazole 1,1'-Carbonyldiimida 1,1'-CarbonyldiiMidazole, >90% N'-CarbonyldiiMidazole (CDI) Product 2: N,N'-CarbonyldiiMidazole N,Nzzhlxy-Carbonyldiimidazole (CDI) CDI (Carbonyl Diimidazole) CARBONYLDIIMIDAZOLE N,N CDI (N,N'-Carbonyldiimidazole) 1,1-Carbonyldiimidazole99% N,N'-Carbonyldiimidazole, 98%+ N,N'-Carbonyl diimidazole (CDI) N,N'-Carbonyldiimidazole,97% N,N'-CARBONYL-BIS-(IMIDAZOLE) N,NCARBONYLDIIMIDAZOLE,HIGHPURITY N,N'-Carbonyldiimidazole 98% 1,1''-CARBONYLDIIMIDZOLE CDI 1,1''-CARBONYLDIIMIDAZOLE N.N''-CARBONYL DICMIDAZOLE 1H-Imidazole,1,1-carbonylbis-(9CI) Bis(iMidazol-1-yl) Ketone Bis(iMidazol-1-yl)Methanone NSC 67203 1,1-CarbonyldiMidazole 1,1'-Carbonylbis-1H-imidazole CDI 1,1'-CarbonyldiiMdazole 1,1''-CARBONYLDIIMIDAZOLE FOR SYNTHESIS CarbonyldiiMaidiazole n,ni-carbonyldiimidazole CDI >=97.0% (T) CDI reagent grade 1,1′-Carbonyldiimidazole solution CDI Vetec(TM) reagent grade, 97% Methanone, di-1H-imidazol-1-yl- N,N-Carbonyldiimidazole≥ 98% (Titration) N,N-Carbonyldiimidazole Manufacturer N’N-Carbonyldiimidazole, CAS No. (Used in manufacture of Ramipril and other drugs) 97.0%(W) 1,1'-Carbonyldiimidazole [Coupling Agent for Peptides Synthesis]> 1,1'-Carbonyldiimidazole, >